Anyone who has played Oregon Trail can attest to the many trailblazers who suddenlyperished from scurvy, a disease caused by a lack of vitamin C. Symptoms of advanced scurvy include pus-filled wounds, teeth loss, spongy gums, and bleeding mucous membranes. Nasty stuff. So what happens in patients with scurvy? Without vitamin C, the body has trouble making stabilized collagen, a protein found in the connective tissues of mammals. Loose tissue prevents wound healing and disrupts tissue integrity, leading to infection if left untreated. While scurvy is less prevalent today, it remains a very real threat to health wherever malnutrition exists, especially in impoverished and underdeveloped countries.