To understand how the brain changes over time in response to new experiences and memories, researchers need a continuous way to visualize new neuronal connections inside the brain of a living animal. Such a technique, known as a chronic cranial window, was developed in 2009 to answer this need. A small bone flap is made in the skull of a mouse and replaced with a sealed glass coverslip, allowing scientists to visualize the brain over time without sacrificing the mouse. This image was obtained through a chronic cranial window, and blood vessels (red) can be seen intermingling with neurons (green).
Image by Mikhail Kislin, University of Helsinki.
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To understand how the brain changes over time in response to new experiences and memories, researchers need a continuous way to visualize new neuronal connections inside the brain of a living animal. Such a technique, known as a chronic cranial window, was developed in 2009 to answer this need. A small bone flap is made in the skull of a mouse and replaced with a sealed glass coverslip, allowing scientists to visualize the brain over time without sacrificing the mouse. This image was obtained through a chronic cranial window, and blood vessels (red) can be seen intermingling with neurons (green).

Image by Mikhail Kislin, University of Helsinki.

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